Thanatin acetate

Description: Thanatin acetate is a cationic peptide with antimicrobial activity, inhibiting the growth of bacteria and fungi by targeting the LptC-LptA interaction and destabilizing the LptA complex involved in lipopolysaccharide transport. Target: Antibacterial. Smiles: NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CCSC)=O)=O)=O)=O)CCCCN)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(N)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O. References: Ma B, et al. The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-beta-lactamase. Nat Commun. 2019 Aug 6,10(1):3517.