Roseltide rT1

Description: Roseltide rT1 is a neutrophil elastase inhibitor (IC50=0.47 µM) and is rich in cysteine, classified as one of the Roseltides (rT1-rT8). It has the potential to inhibit related diseases by improving neutrophil elastase-stimulated cAMP accumulation in vitro. Target: Serine Protease. Smiles: O=C1N2[C@](C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCC(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@]3(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@]4(C(=O)N[C@@](CSSC[C@H](N)C(=O)N[C@]1([C@H](CC)C)[H])(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N5[C@@](CCC5)(C(=O)NCC(=O)N[C@@](CSSC3)(C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)NCC(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@H](C(N[C@H](C(O)=O)C)=O)CSSC4)[H])[H])[H])[H])[H])[H])[H])[H])(CCC2)[H]