RES-701-1

Description: RES-701-1 is a cyclic peptide consisting of 16 common L-amino acids. It acts as a specific antagonist of the ETB receptor. RES-701-1 inhibits the binding of 125I-ET-1 (125I-labeled endothelin (ET)-1) to the ETB receptor, with an IC50 value of 10 nM. Target: Endothelin Receptor. Smiles: C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC=5C=6C(NC5)=CC=CC6)C(O)=O)=O)=O)=O)CC(N)=O)=O)=O)=O)NC(=O)[C@H]7NC(=O)[C@]8(N(CCC8)C(=O)[C@H](C)NC(=O)[C@]([C@@H](C)O)(NC(=O)CNC(=O)[C@H](CC9=CN=CN9)NC(=O)[C@H](CC=%10C=%11C(NC%10)=CC=CC%11)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)C7)[H])[H])C=%12C=%13C(NC%12)=CC=CC%13