QWF acetate

Description: QWF acetate is a Substance P antagonist that specifically inhibits the binding of Substance P to its receptor (NK1) with an IC50 of 0.09 Mm, it can also inhibit the activation of Mas-related G-protein-coupled receptor X2 (MRGPRX2), which inhibits degranulation of mast cells.QWF acetate is used as a polypeptide in pain, inflammation and allergic reactions, QWF acetate has important applications as a peptide in the study of pain, inflammation and allergic reactions. Target: Neurokinin receptor. Smiles: O=C(OCC1=CC=CC=C1)[C@H](CC2=CC=CC=C2)NC([C@H](NC([C@H](CCC(N)=O)NC(OC(C)(C)C)=O)=O)CC3=CN(C=O)C4=CC=CC=C34)=O.OC(C)=O. References: Hagiwara D, et al. Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J Med Chem. 1992 May 29,35(11):2015-25.