Polyglutamine binding peptide 1

Description: Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor of polyglutamine (polyQ). It effectively inhibits polyQ protein aggregation in vitro and prevents polyQ-induced cell death in cell cultures. Target: Huntingtin. Smiles: C([C@@H](C(=O)N1[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)[C@H](CC)C)=O)=O)CCC1)NC([C@H](CC=3C=4C(NC3)=CC=CC4)NC([C@@H](NC([C@H](CC=5C=6C(NC5)=CC=CC6)NC([C@@H](NC([C@H](CO)N)=O)CC(N)=O)=O)=O)CCCCN)=O)=O)C=7C=8C(NC7)=CC=CC8