PKC zeta pseudosubstrate

Description: Inhibitor of protein kinase C (PKC) zeta, attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC zeta pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC zeta-independent pathway. References: Laudanna et al (1998) Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. J.Biol.Chem 273 30306 PMID: