PF-1022A

PF-1022A is a cyclodepsipeptide fungal metabolite originally isolated from mycelia sterilia and has anthelmintic activity. Oral administration of PF-1022A (0.5-2 mg/kg) induces worm excretion in a chicken model of A. galli infection. It induces parasite clearance in jird models of H. contortus, O. ostertagi, or T. colubriformis infection (ED95s = 0.11, 0.33, and 0.11 mg/animal).Formal Name: cyclo[(alphaR)-alpha-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(alphaR)-alpha-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]. CAS Number: 133413-70-4. Molecular Formula: C52H76N4O12. Formula Weight: 949.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 43 mg/ml. SMILES: O=C(N(C)[C@@H](CC(C)C)C(O[C@H](CC1=CC=CC=C1)C(N([C@@H](CC(C)C)C(O[C@H](C)C(N2C)=O)=O)C)=O)=O)[C@@H](C)OC([C@H](CC(C)C)N(C)C([C@@H](CC3=CC=CC=C3)OC([C@@H]2CC(C)C)=O)=O)=O. InChi Code: InChI=1S/C52H76N4O12/c1-31(2)25-39-49(61)65-35(9)45(57)53(11)42(28-34(7)8)52(64)68-44(30-38-23-19-16-20-24-38)48(60)56(14)40(26-32(3)4)50(62)66-36(10)46(58)54(12)41(27-33(5)6)51(63)67-43(47(59)55(39)13)29-37-21-17-15-18-22-37/h15-24,31-36,39-44H,25-30H2,1-14H3/t35-,36-,39+,40+,41+,42+,43-,44-/m1/s1. InChi Key: YJNUXGPXJFAUQJ-LYWANRAQSA-N. Origin: Synthetic.