Muramyl Dipeptide

Muramyl dipeptide (MDP) is a ligand for nucleotide-binding oligomerization domain-containing 2 (NOD2) and a breakdown product of bacterial cell wall peptidoglycan. MDP binds to NOD2 to induce NF-kappaB signaling and the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. It has been used as an adjuvant to enhance non-specific immunity to bacterial infections in mice.Formal Name: N-(N-acetylmuramoyl)-L-alanyl-D-alpha-glutamine. CAS Number: 53678-77-6. Synonyms: MDP, N-Acetylmuramoyl dipeptide. Molecular Formula: C19H32N4O11. Formula Weight: 492.5. Purity: >95% (mixture of anomers). Formulation: (Request formulation change), A solid. Solubility: Water: 40 mg/ml. SMILES: OC[C@@H](O)[C@@H](O)[C@H](O[C@@H](C(N[C@@H](C)C(N[C@@H](C(N)=O)CCC(O)=O)=O)=O)C)[C@@H](NC(C)=O)C=O. InChi Code: InChI=1S/C19H32N4O11/c1-8(18(32)23-11(17(20)31)4-5-14(28)29)21-19(33)9(2)34-16(15(30)13(27)7-25)12(6-24)22-10(3)26/h6,8-9,11-13,15-16,25,27,30H,4-5,7H2,1-3H3,(H2,20,31)(H,21,33)(H,22,26)(H,23,32)(H,28,29)/t8-,9+,11+,12-,13+,15+,16+/m0/s1. InChi Key: MEJOVVKHFORGKW-HOMBLFBHSA-N.