mSIRK

Description: mSIRK (G-Protein betagamma Binding Peptide) is a cell-permeable activator of ERK 1/2 with an EC50 of 2.5-5 µM. It disrupts the interaction between the alpha and betagamma subunits, facilitating alpha subunit dissociation without inducing nucleotide exchange [1]. Target: ERK. Smiles: C([C@H](CC1=CC=C(O)C=C1)NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCCC CCC)=O)CO)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCCN)=O)C)=O)CC(C)C)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)=O)(=O)N2[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)CC(O)=O)=O)CCC2