Macrophage-activating lipopeptide 2

Description: Macrophage-activating lipopeptide 2 (MALP-2) is a lipopeptide that acts as an agonist for Toll-like receptors TLR-2 and TLR-6. It enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, thereby improving vasodilation. Additionally, MALP-2 increases the adhesion of leukocytes to the endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL). Smiles: [C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCC(O)=O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CSC[C@@H](COC(CCCCCCCCCC CCCCC)=O)OC(CCCCCCCCCCCCCCC)=O)N)=O)=O)CC(N)=O)=O)CC(N)=O)=O)CC(O)=O)=O)CCC(O)=O)=O)CO)=O)CC(N)=O)=O)[C@H](CC)C)=O)CO)=O