M. tuberculosis Alpha-crystallin Peptide Pool

Pool of 34 peptides derived from a peptide scan (15mers with 11 aa overlap) through Alpha-crystallin (Uni-Prot ID: P9WMK1) of M. Tuberculosis - strain ATCC 25618 / H37Rv. One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. [The UniProt Consortium]