LXW7 TFA (1313004-77-1 free base)

Description: LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin alphavbeta3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to alphavbeta3 integrin (IC50: 0.68 µM). It increases the phosphorylation of VEGFR-2 and activation of ERK1/2. Target: Integrin. References: Xiao W, et al. The use of one-bead one-compound combinatorial library technology to discover high-affinity alphavbeta3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct,9(10):2714-23.