[Leu144,Arg147]-PLP (139-151)

Description: [Leu144,Arg147]-PLP (139-151) is a modified peptide fragment derived from myelin proteolipid protein (PLP), where leucine and arginine have replaced tryptophan and histidine at positions 144 and 147, respectively. This mutant also functions as a T cell receptor (TCR) antagonist, inhibiting the activation of encephalitogenic Th1 clones in vitro. Additionally, [Leu144,Arg147]-PLP (139-151) can impede the progression of experimental autoimmune encephalomyelitis (EAE). Smiles: C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)CCCCN)=O)CC(O)=O)(=O)[C@H]2N(C([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC3=CN=CN3)N)=O)CO)=O)CC(C)C)=O)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CCC2