KP-6

Description: KP-6 is a peptide that acts as an inhibitor of the Wnt/beta-catenin signaling pathway. It suppresses TGF-beta and disrupts key signals that lead to rapid fibrosis in vivo. KP-6 helps prevent kidney tissue damage and fibrosis, offering the potential to reverse the progression of chronic kidney disease (CKD). Smiles: C([C@H](NC([C@H](CC1=CN=CN1)NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C([C@H](CCC(N)=O)N)=O)CCC3)[C@@H](C)C)=O)C(C)C)=O)[C@@H](C)O)=O)CC(C)C)=O)=O)=O)C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(NCC(NCC(N[C@@H](CC=6C=7C(NC6)=CC=CC7)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC8=CN=CN8)C(O)=O)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)C)=O)=O)=O)=O)=O)C)=O)CC(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCC4)CC(C)C)=O)CC(O)=O)=O)C=9C=%10C(NC9)=CC=CC%10