KGYY15

Description: KGYY15 (Mouse KGYY15), a peptide that targets CD40, exhibits weak inhibition of the CD40-CD40L interaction, with an IC50 exceeding 1 mM. At a concentration of 100 µM, KGYY15 activates the NF-kappaB pathway by 33%. Target: TNF. Smiles: C([C@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)CC(C)C)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)CO)=O)CCCCN)=O)CCSC)=O)[C@@H](C)O)=O)=O)=O)=O)CCCCN)=O)CCCCN)=O)C)=O)C=3C=4C(NC3)=CC=CC4