HL2-m5

Description: HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM. Target: Hedgehog/Smoothened. Smiles: C([C@@H](C(N[C@H]1CC=2C=CC(=CC2)OCCSC[C@@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N)=O)=O)[C@@H](C)O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC1=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)C=3C=4C(NC3)=CC=CC4