HBP08

Description: HBP08 is a selective inhibitor that disrupts the interaction between CXCL12 and HMGB1. It demonstrates a high affinity for HMGB1 with a dissociation constant (K d) of 0.8 µM and effectively inhibits cell migration induced by CXCL12. Smiles: C([C@@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(O)=O)=O)[C@H](CC)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CC3=CN=CN3)NC([C@H](CC4=CC=C(O)C=C4)NC(CN)=O)=O)=O)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)C=5C=6C(NC5)=CC=CC6