GeX-2

Description: GeX-2 is a truncated analogue of alphaO-conotoxin. It has the ability to activate GABAB receptors and inhibit alpha9alpha10nAChR as well as CaV2.2 channels. Additionally, GeX-2 is effective in alleviating pain in a rat model of chronic constriction injury. Target: Calcium Channel, AChR, GABA Receptor. Smiles: C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N)=O)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(O)=O)=O)(=O)[C@H]3N(C([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CCCNC(=N)N)NC(CN)=O)=O)=O)CCCNC(=N)N)=O)CO)=O)CCC3