FNIII14 (sodium salt)

FNIII14 is an inhibitor of cell adhesion and a peptide derived from the 14th type III repeat, which is part of heparin-binding domain 2, of human, mouse, and rat fibronectin. It inhibits the adhesion of A375-SM melanoma cells to fibronectin-coated plates when used at a concentration of 200 µg/ml. FNIII14 (100 µg/ml) inhibits the binding of an antibody targeting the active conformation of the fibronectin receptor beta1 integrin on K562 cells, which endogenously express integrin alpha5beta1 as its only beta1 integrin, and induces the differentiation of ST 13 fibroblasts into adipocytes. It decreases atherosclerotic plaque formation in Ldlr-/- mice fed a Western diet. FNIII14, in combination with the antitumor antibiotic doxorubicin (Cay-15007), reduces metastatic tumor burden in a 4T1 murine mammary model of metastasis.Formal Name: L-threonyl-L-alpha-glutamyl-L-alanyl-L-threonyl-L-isoleucyl-L-threonylglycyl-L-leucyl-L-alpha-glutamyl-L-prolylglycyl-L-threonyl-L-alpha-glutamyl-L-tyrosyl-L-threonyl-L-isoleucyl-L-tyrosyl-L-valyl-L-isoleucyl-L-alanyl-L-leucine, sodium salt. Synonyms: FNIII14-2. Molecular Formula: C103H163N21O35 . XNa. Formula Weight: 2255.5. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: TEATITGLEPGTWYTIYVIAL-OH. Solubility: DMSO: Soluble: >10 mg/mL. SMILES: [H]N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@@H](C)O)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N1CCC[C@H]1C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](C(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)C)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O.[Na]. InChi Code: InChI=1S/C103H163N21O35.Na/c1-20-49(10)78(96(151)108-52(13)85(140)115-69(103(158)159)41-47(6)7)118-95(150)77(48(8)9)117-90(145)68(43-60-27-31-62(131)32-28-60)114-97(152)79(50(11)21-2)119-101(156)84(58(19)129)122-91(146)67(42-59-25-29-61(130)30-26-59)113-88(143)64(34-37-74(136)137)111-99(154)82(56(17)127)116-72(133)45-105-92(147)70-24-23-39-124(70)102(157)65(35-38-75(138)139)112-89(144)66(40-46(4)5)109-71(132)44-106-94(149)81(55(16)126)123-98(153)80(51(12)22-3)120-100(155)83(57(18)128)121-86(141)53(14)107-87(142)63(33-36-73(134)135)110-93(148)76(104)54(15)125,/h25-32,46-58,63-70,76-84,125-131H,20-24,33-45,104H2,1-19H3,(H,105,147)(H,106,149)(H,107,142)(H,108,151)(H,109,132)(H,110,148)(H,111,154)(H,112,144)(H,113,143)(H,114,152)(H,115,140)(H,116,133)(H,117,145)(H,118,150)(H,119,156)(H,120,155)(H,121,141)(H,122,146)(H,123,153)(H,134,135)(H,136,137)(H,138,139)(H,158,159),/t49-,50-,51-,52-,53-,54+,55+,56+,57+,58+,63-,64-,65-,66-,67-,68-,69-,70-,76-,77-,78-,79-,80-,81-,82-,83-,84-,/m0./s1. InChi Key: WZQPLUSPERBDPM-VHCTWGPZSA-N.