FKBP6_HUMAN Peptide Pool

Pool of 79 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (UniProt ID: O75344) of Homo sapiens (Human). One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by- products from Piwi complexes, possibly facilitating turnover of Piwi complexes. [The UniProt Consortium]