EPI-X4

Description: EPI-X4 (hSA408â?"423 peptide), with an IC50 of 8.6 µM, serves as an antagonist for the C-X-C motif chemokine receptor 4 (CXCR4). It inhibits CXCL12-mediated signaling and reduces chemokine-driven migration and invasion of leukemia cells. Furthermore, it demonstrates anti-inflammatory effects in a mouse model and possesses antiviral properties against CXCR4-tropic HIV, maintaining the same IC50. Target: CXCR. Smiles: C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CCCCN)=O)[C@@H](C)C)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@@H](C)O)=O)CCC3)[C@@H](C)O)=O)CO)=O)[C@H](C)C)=O)CCC(N)=O)=O)CCC2