Emodepside

Emodepside is a macrocyclic depsipeptide anthelmintic and semisynthetic derivative of the fungal metabolite and anthelmintic PF-1022A (Cay-29700). It inhibits locomotion in C. elegans (IC50 = 14 nM), an effect that can be reversed by knockout of the gene encoding the calcium-activated potassium channel SLO-1. Emodepside (10 mg/kg) decreases the survival of N. brasiliensis and S. ratti worms in infected rats and H. polygyrus worms in infected mice. Formulations containing emodepside in combination with praziquantel have been used as anthelmintics in cats and dogs.Formal Name: cyclo[(alphaR)-alpha-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(alphaR)-alpha-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]. CAS Number: 155030-63-0. Synonyms: BAY-44-4400, PF-1022-221. Molecular Formula: C60H90N6O14. Formula Weight: 1119.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml. SMILES: O=C(N([C@H](C(O[C@@H](C(N([C@H](C(O[C@@H]1CC2=CC=C(N3CCOCC3)C=C2)=O)CC(C)C)C)=O)C)=O)CC(C)C)C)[C@H](OC([C@@H](N(C([C@H](OC([C@@H](N(C1=O)C)CC(C)C)=O)C)=O)C)CC(C)C)=O)CC4=CC=C(N5CCOCC5)C=C4. InChi Code: InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1. InChi Key: ZMQMTKVVAMWKNY-YSXLEBCMSA-N.