Davunetide (acetate)

Davunetide is a neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP). It promotes tubulin assembly in a cell-free assay when used at a concentration of 1 fM. Davunetide (1 fM) protects against cytotoxicity induced by tetrodotoxin (Cay-14963, Cay-14964), a peptide derived from amyloid-beta (Abeta), or zinc in isolated neonatal cerebral cortical cells. Intravitreal administration of davunetide (4 µl of a 100 µg/ml solution) inhibits increases in cleaved caspase-3 and decreases in Bcl-2 levels in retina isolated from streptozotocin-induced diabetic rats. It improves survival in a superoxide dismutase 1 mutant (SOD1G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS) when administered at 10 µg/animal. Davunetide prevents decreases in brain choline acetyltransferase (ChAT) activity and prevents memory deficits in the Morris water maze in an Apoe-/- mouse model of neurodegeneration.Formal Name: L-asparaginyl-L-alanyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-glutamine, acetate. Synonyms: AL-108, NAP, NAPVSIPQ. Molecular Formula: C36H60N10O12 . XC2H4O2. Formula Weight: 824.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: insol, PBS (pH 7.2): 10 mg/ml. SMILES: O=C([C@H]1N(CCC1)C([C@H](C)NC([C@@H](N)CC(N)=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O.CC(O)=O. InChi Code: InChI=1S/C36H60N10O12.C2H4O2/c1-6-18(4)28(35(56)46-14-8-9-23(46)31(52)41-21(36(57)58)11-12-25(38)48)44-30(51)22(16-47)42-33(54)27(17(2)3)43-32(53)24-10-7-13-45(24)34(55)19(5)40-29(50)20(37)15-26(39)49,1-2(3)4/h17-24,27-28,47H,6-16,37H2,1-5H3,(H2,38,48)(H2,39,49)(H,40,50)(H,41,52)(H,42,54)(H,43,53)(H,44,51)(H,57,58),1H3,(H,3,4)/t18-,19-,20-,21-,22-,23-,24-,27-,28-,/m0./s1. InChi Key: FKFJZZGKZSKPFE-XVHDDEJMSA-N.