[D-Ser14]-Humanin

Description: [D-Ser14]-Humanin is a biologically active peptide in which the Ser14 residue of Humanin is replaced with its D-form. This variant exhibits effective inhibitory activity against the fibrillation of amyloid-beta. Compared to its L-form counterpart, [D-Ser14]-Humanin offers enhanced cellular protective activity against age-related cell death induced by amyloid precursor fibrils and oxidative stress. This compound is utilized in research on Alzheimers disease. Smiles: C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC(CNC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CCSC)N)=O)C)=O)CCC2)CCCNC(=N)N)=O)=O)=O)CO)=O)CS)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)[C@@H](C)O)=O)CO)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC(O)=O)=O)CC(C)C)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N[C@H](C(O)=O)C)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)[C@H](C)C)=O)CCC3