D-CopA3

Description: D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 µM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model. Target: Autophagy, MDM-2/p53. Smiles: [C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CCCCN)C(N)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)[C@@H](CC)C)=O)(NC([C@H](NC([C@@H](CC(C)C)N)=O)CC(C)C)=O)CSSC[C@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](CCCCN)C(N)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)[C@@H](CC)C)=O)NC([C@H](NC([C@@H](CC(C)C)N)=O)CC(C)C)=O