CT-08

Description: CT-08 (CT8, Compound 3) is a macrolide Sec61 modulator that inhibits protein secretion in a signal sequence-dependent manner. It prevents the Sec61-mediated translocation of VCAMss-GLuc to the ER, resulting in the loss of luciferase activity. Additionally, CT-08 suppresses the expression of VCAM in transfected cells. Target: Others. Smiles: C([C@H]1C(=O)N[C@@H](C[C@@H](CCCC)C)C(=O)N(C)[C@@H](C)C(=O)O[C@H](CC#C)C(=O)N[C@@H](C[C@@H](CCCC)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1C)C2=CC=CC=C2