Cilengitide

Description: Cilengitide (EMD 121974) is a potent integrin inhibitor for the alphavbeta3/5 receptor (IC50: 4.1/79 nM, in cell-free assays) with approximately 10-fold selectivity against gpIIbIIIa. Target: Apoptosis, Integrin, PD-1/PD-L1, STAT, Autophagy. Smiles: CC(C)[C@@H]1N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC1=O