aStAx-35R

Description: aStAx-35R is a stapled peptide that antagonizes the nuclear form of beta-catenin, thereby inhibiting Wnt signaling. It competitively inhibits the binding of beta-catenin to TCF4. Additionally, aStAx-35R selectively induces growth inhibition in Wnt-dependent cancer cells. Target: Wnt/beta-catenin. Smiles: C([C@@H](C(=O)N1[C@H](C(N[C@H](C(N[C@]2(C)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)=O)C(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)[C@@H](C)C)=O)=O)(C)CCCC=CCCC2)[H])=O)CCCNC(=N)N)=O)CCC1)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O)C=6C=7C(NC6)=CC=CC7