alpha-Conotoxin GID

Description: alpha-Conotoxin GID is a paralytic peptide neurotoxin that selectively antagonizes nAChR with IC50 values of 5 nM (alpha7), 3 nM (alpha3beta2), and 150 nM (alpha4beta2). This small, disulfide-rich peptide has potential for chronic pain inhibition. The presence of a C-terminal carboxylate is crucial, as substitution with a C-terminal carboxamide results in loss of activity against alpha4beta2 nAChR. Derived from species of the genus Conus [1] [2] [3].