123B9

Description: 123B9 is a tumor-homing agent characterized as a potent and selective agonist for EphA2 with a dissociation constant (Kd) of 4.0 µM. It specifically targets the ligand-binding domain of the EphA2 tyrosine kinase receptor. Notably, 123B9 does not significantly inhibit the ligand-binding domains of closely related receptors EphA3 and EphA4. Target: Ephrin Receptor. Smiles: C([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC(COC2=CC(Cl)=C(F)C=C2)=O)CO)=O)C)=O)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCO)=O)CCCC)=O)CCC4)[C@@H](C)C)=O)CO)=O)CC(O)=O)=O)CCC3