Hemoglobin C Control Peptide

Greater than 95% specific peptide HbC peptite corresponds to the E6K mutant in the amino-termianl portion of hemoglobin beta subunit. Functional hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (alpha2beta2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Less significant than the SCD-E6V, HbC E6K mutation causes a mild hemolytic anemia. HbC peptide is suitable for use as a control with the HbC antibody. This peptide is ideal for investigators involved in Cardiovascular and developmental biology research.