APRIL, ED2, Blocking Peptide (a Proliferation Inducing Ligand, TALL-2, TNF and ApoL-related Leukocyt

Synthetic peptide (CIRSMPSHPDRAYNS) corresponding to amino acids 196 to 210 of human APRIL (1-3). Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identi?ed by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF-and ApoL-related Leukocyte-expressed Ligand 2), and TRDL-1a (for TNF related death ligand 1a) in human and mouse (1-4). Two receptors for APRIL were recently identi?ed and designated TACI and BCMA (5-7). APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death (1-7). APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer (8,9). , Applications: Suitable for use in ELISA and Western Blot. Other applications not tested., , Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute to nominal volume by adding sterile 25% glycerol and store at -20°C. May be stored at 4°C for short-term only. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.