P4HTM (Vector pUC, Accession No. BC011710)

Length: 1500 Sequence: atggtgttcg tgcacctgta cctgggtaac gtgctggcgc tgctgctctt cgtgcactac agcaacggcg acgaaagcag cgatcccggg ccccaacacc gtgcccaggg ccccgggccc gagcccacct taggtcccct cacccggctg gagggcatca aggtggggca cgagcgtaag gtccagctgg tcaccgacag ggatcacttc atccgaaccc tcagcctcaa gccgctgctc ttcgaaatcc ccggcttcct gactgatgaa gagtgtcggc tcatcatcca tctggcgcag atgaaggggt tacagcgcag ccagatcctg cctactgaag agtatgaaga ggcaatgagc actatgcagg tcagccagct ggacctcttc cggctgctgg accagaaccg tgatgggcac cttcagctcc gtgaggttct ggcccagact cgcctgggaa atggatggtg gatgactcca gagagcattc aggagatgta cgccgcgatc aaggctgacc ctgatggtga cggagtgctg agtctgcagg agttctccaa catggacctt cgggacttcc acaagtacat gaggagccac aaggcagagt ccagtgagct ggtgcggaac agccaccata cctggctcta ccagggtgag ggtgcccacc acatcatgcg tgccatccgc cagagggtgc tgcgcctcac tcgcctgtcg cctgagatcg tggagctcag cgagccgctg caggttgttc gatatggtga ggggggccac taccatgccc acgtggacag tgggcctgtg tacccagaga ccatctgctc ccataccaag ctggtagcca acgagtctgt acccttcgag acctcctgcc ggcaagtatc tcccaactgg gggctgcctt caatcctcag accaggaaca cccatgacac aggcacagcc ctgcactgtg ggcgtgcccc ttggcatggg gccaggagat cactgggtta tcccggtaag cccctgggag catccacaac tggggacctg ctcagtgccc cccctgcctt acagctacat gacagtgctg ttttatttga acaacgtcac tggtgggggc gagactgttt tccctgtagc agataacaga acctacgatg aaatgagtct gattcaggat gacgtggacc tccgtgacac acggaggcac tgtgacaagg gaaacctgcg tgtcaagccc caacagggca cagcagtctt ctggtacaac tacctgcctg atgggcaagg ttgggtgggt gacgtagacg actactcgct gcacgggggc tgcctggtca cgcgcggcac caagtggatt gccaacaact ggattaatgt ggaccccagc cgagcgcggc aagcgctgtt ccaacaggag atggcccgcc ttgcccgaga agggggcacc gactcacagc ccgagtgggc tctggaccgg gcctaccgcg atgcgcgcgt Protein function: Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. [The UniProt Consortium]