Zu "K06711" wurden 20 Artikel gefunden!
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DMOG
Artikelnummer: Cay71210-100
The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1alpha prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1alpha...
| Schlagworte: | Dimethyloxallyl Glycine, N-(methoxyoxoacetyl)-glycine, methyl ester |
| Anwendung: | HIF-PH inhibitor |
| CAS | 89464-63-1 |
| MW: | 175.1 D |
ab 27,00 €
P4HTM Protein, Human, Recombinant (His & SUMO)
Artikelnummer: TGM-TMPH-02233-100ug
Description: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation...
| Schlagworte: | P4HTM, Hypoxia-inducible factor prolyl hydroxylase 4, Transmembrane prolyl 4-hydroxylase |
| MW: | 70.5 kD |
ab 198,00 €
DMOG
Artikelnummer: TGM-T1939-100mg
Description: DMOG (Dimethyloxalylglycine), an antagonist of the alpha-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase. Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy. Smiles: COC(=O)CNC(=O)C(=O)OC. References: Singh A, et al. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors...
| Schlagworte: | Dimethyloxallyl Glycine, Dimethyloxalylglycine, Dimethyloxaloylglycine |
| Anwendung: | HIF-PH inhibitor |
| CAS | 89464-63-1 |
| MW: | 175.14 D |
ab 46,00 €
JNJ-42041935
Artikelnummer: TGM-T3180-100mg
Description: JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. Target: HIF/HIF Prolyl-Hydroxylase. Smiles: OC(=O)c1cnn(c1)-c1nc2cc(Cl)c(OC(F)(F)F)cc2[nH]1. References: Barrett TD, et al. Pharmacological characterization of...
| Schlagworte: | HIF-PHD Inhibitor II |
| Anwendung: | HIF-PH4 inhibitor |
| CAS | 1193383-09-3 |
| MW: | 346.65 D |
ab 34,00 €
Transmembrane prolyl 4-hydroxylase (P4HTM), partial,...
Artikelnummer: CSB-EP878913HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 82-563aa. Protein Length: Partial of Isoform 3. Tag Info: N-terminal 6xHis-SUMO-tagged. Target Protein Sequence: VHYSNGDESS DPGPQHRAQG PGPEPTLGPL TRLEGIKVGH ERKVQLVTDR DHFIRTLSLK PLLFEIPGFL TDEECRLIIH LAQMKGLQRS QILPTEEYEE AMSTMQVSQL DLFRLLDQNR...
| Schlagworte: | PH4, HPH-4, P4HTM, P4H-TM, HIF-PH4, HIF-prolyl hydroxylase 4, Transmembrane prolyl 4-hydroxylase, Hypoxia-inducible factor... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 70.5 kD |
ab 219,00 €
2,4-DPD
Artikelnummer: Cay71200-10
The pro-angiogenic factor HIF-1alpha is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-alpha prolyl hydroxylase (HIF-PH). 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of...
| Schlagworte: | 2,4-Diethylpyridine dicarboxylate, 2,4-pyridinedicarboxylic acid, diethyl ester |
| Anwendung: | HIF-PH inhibitor |
| CAS | 41438-38-4 |
| MW: | 223.2 D |
ab 27,00 €
JNJ-42041935
Artikelnummer: Cay14316-5
JNJ-42041935 is a selective, 2-OG competitive, and reversible inhibitor of HIF-PH enzymes (pKis = 12.3, 51.3, and 22.4 nM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is >100-fold selective for HIF-PH compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes. In an...
| Schlagworte: | HIF-PHD Inhibitor II, 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1H-pyrazole-4-carboxylic acid |
| Anwendung: | HIF-PH4 inhibitor |
| CAS | 1193383-09-3 |
| MW: | 346.7 D |
ab 85,00 €
1,4-DPCA
Artikelnummer: Cay71220-10
The pro-angiogenic factor HIF-1alpha is targeted for destruction in non-hypoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-alpha prolyl hydroxylase (HIF-PH). Inhibitors of prolyl 4-hydroxylase are potentially useful in controlling excess collagen...
| Schlagworte: | 1,4-dihydrophenonthrolin-4-one-3-Carboxylic acid, 4,4alpha-dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid |
| Anwendung: | Prolyl 4-hydroxylase inhibitor |
| CAS | 331830-20-7 |
| MW: | 240.2 D |
ab 67,00 €
Anti-PHD4
Artikelnummer: A300-330A
Protein function: Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal...
| Schlagworte: | Anti-PH4, Anti-P4HTM, Anti-HPH-4, Anti-P4H-TM, Anti-HIF-PH4, EC=1.14.11.-, Anti-HIF-prolyl hydroxylase 4,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 178,00 €
1,4-DPCA
Artikelnummer: LKT-D6108.25
Prolyl hydroxylase inhibitor.
| Schlagworte: | 1,4-Dihydrophenonthrolin-4-one-3-carboxylic acid, 3-Acetyl-1H-[1,10]phenanthrolin-4-one,... |
| Anwendung: | Prolyl hydroxylase inhibitor |
| CAS | 331830-20-7 |
| MW: | 240.22 D |
ab 76,00 €
Anti-P4HTM
Artikelnummer: ATA-HPA007199.100
Protein function: Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal...
| Schlagworte: | Anti-PH4, Anti-HPH-4, Anti-P4HTM, Anti-P4H-TM, Anti-HIF-PH4, Anti-HIF-prolyl hydroxylase 4, Anti-Transmembrane prolyl... |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
477,00 €
Anti-P4HTM Recombinant
Artikelnummer: ABS-RC-5739.100
Protein function: Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal...
| Schlagworte: | Anti-Transmembrane prolyl 4-hydroxylase, Anti-P4H-TM, Anti-Hypoxia-inducible factor prolyl hydroxylase 4, Anti-HIF-PH4,... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 232,00 €