NOD1 (Vector pENTR223.1, Accession No. BC040339)

Length: 2862 Sequence: atggaagagc agggccacag tgagatggaa ataatcccat cagagtctca cccccacatt caattactga aaagcaatcg ggaacttctg gtcactcaca tccgcaatac tcagtgtctg gtggacaact tgctgaagaa tgactacttc tcggccgaag atgcggagat tgtgtgtgcc tgccccaccc agcctgacaa ggtccgcaaa attctggacc tggtacagag caagggcgag gaggtgtccg agttcttcct ctacttgctc cagcaactcg cagatgccta cgtggacctc aggccttggc tgctggagat cggcttctcc ccttccctgc tcactcagag caaagtcgtg gtcaacactg acccagtgag caggtatacc cagcagctgc gacaccatct gggccgtgac tccaagttcg tgctgtgcta tgcccagaag gaggagctgc tgctggagga gatctacatg gacaccatca tggagctggt tggcttcagc aatgagagcc tgggcagcct gaacagcctg gcctgcctcc tggaccacac caccggcatc ctcaatgagc agggtgagac catcttcatc ctgggtgatg ctggggtggg caagtccatg ctgctacagc ggctgcagag cctctgggcc acgggccggc tagacgcagg ggtcaaattc ttcttccact ttcgctgccg catgttcagc tgcttcaagg aaagtgacag gctgtgtctg caggacctgc tcttcaagca ctactgctac ccagagcggg accccgagga ggtgtttgcc ttcctgctgc gcttccccca cgtggccctc ttcaccttcg atggcctgga cgagctgcac tcggacttgg acctgagccg tgtgcctgac agctcctgcc cctgggagcc tgcccacccc ctggtcttgc tggccaacct gctcagtggg aagctgctca agggggctag caagctgctc acagcccgca caggcatcga ggtcccgcgc cagttcctgc ggaagaaggt gcttctccgg ggcttctccc ccagccacct gcgcgcctat gccaggagga tgttccccga gcgggccctg caggaccgcc tgctgagcca gctggaggcc aaccccaacc tctgcagcct gtgctctgtg cccctcttct gctggatcat cttccggtgc ttccagcact tccgtgctgc ctttgaaggc tcaccacagc tgcccgactg cacgatgacc ctgacagatg tcttcctcct ggtcactgag gtccatctga acaggatgca gcccagcagc ctggtgcagc ggaacacaca cagcccagtg gagaccctcc acgccggccg ggacactctg tgctcgctgg ggcaggtggc ccaccggggc atggagaaga gcctctttgt cttcacccag gaggaggtgc aggcctccgg gctgcaggag agagacatgc agctgggctt cctgcgggct ttgccggagc tgggccccgg gggtgaccag cagtcctatg agtttttcca cctcaccctc caggccttct ttacagcctt cttcctcgtg ctggacgaca gggtgggcac tcaggagctg ctcaggttct tccaggagtg gatgccccct gcgggggcag cgaccacgtc ctgctatcct cccttcctcc cgttccagtg cctgcagggc agtggtccgg cgcgggaaga cctcttcaag aacaaggatc acttccagtt caccaacctc ttcctgtgcg ggctgttgtc caaagccaaa cagaaactcc tgcggcatct ggtgcccgcg gcagccctga ggagaaagcg caaggccctg tgggcacacc tgttttccag cctgcggggc tacctgaaga gcctgccccg cgttcaggtc gaaagcttca accaggtgca ggccatgccc acgttcatct ggatgctgcg ctgcatctac gagacacaga gccagaaggt ggggcagctg gcggccaggg gcatctgcgc caactacctc aagctgacct actgcaacgc ctgctcggcc gactgcagcg ccctctcctt cgtcctgcat cacttcccca agcggctggc cctagaccta gacaacaaca atctcaacga ctacggcgtg cgggagctgc agccctgctt cagccgcctc actgttctca gactcagcgt aaaccagatc actgacggtg gggtaaaggt gctaagcgaa gagctgacca aatacaaaat tgtgacctat ttgggtttat acaacaacca gatcaccgat gtcggagcca ggtacgtcac caaaatcctg gatgaatgca aaggcctcac gcatcttaaa ctgggaaaaa acaaaataac aagtgaagga gggaagtatc tcgccctggc tgtgaagaac agcaaatcaa tctctgaggt tgggatgtgg ggcaatcaag ttggggatga aggagcaaaa gccttcgcag aggctctgcg gaaccacccc agcttgacca ccctgagtct tgcgtccaac ggcatctcca cagaaggagg aaagagcctt gcgagggccc tgcagcagaa cacgtctcta gaaatactgt ggctgaccca aaatgaactc aacgatgaag tggcagagag tttggcagaa atgttgaaag tcaaccagac gttaaagcat ttatggctta tccagaatca gatcacagct aaggggactg cccagctggc agatgcgtta cagagcaaca ctggcataac agagatttgc ctaaatggaa acctgataaa accagaggag gccaaagtct atgaagatga gaagcggatt atctgtttct Protein function: Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection. [The UniProt Consortium]