DGAT2 (Vector pENTR223.1, Accession No. BC015234)

Length: 1167 Sequence: atgaagaccc tcatagccgc ctactccggg gtcctgcgcg gcgagcgtca ggccgaggct gaccggagcc agcgctctca cggaggacct gcgctgtcgc gcgaggggtc tgggagatgg ggcactggat ccagcatcct ctccgccctc caggacctct tctctgtcac ctggctcaat aggtccaagg tggaaaagca gctacaggtc atctcagtgc tccagtgggt cctgtccttc cttgtactgg gagtggcctg cagtgccatc ctcatgtaca tattctgcac tgattgctgg ctcatcgctg tgctctactt cacttggctg gtgtttgact ggaacacacc caagaaaggt ggcaggaggt cacagtgggt ccgaaactgg gctgtgtggc gctactttcg agactacttt cccatccagc tggtgaagac acacaacctg ctgaccacca ggaactatat ctttggatac cacccccatg gtatcatggg cctgggtgcc ttctgcaact tcagcacaga ggccacagaa gtgagcaaga agttcccagg catacggcct tacctggcta cactggcagg caacttccga atgcctgtgt tgagggagta cctgatgtct ggaggtatct gccctgtcag ccgggacacc atagactatt tgctttcaaa gaatgggagt ggcaatgcta tcatcatcgt ggtcgggggt gcggctgagt ctctgagctc catgcctggc aagaatgcag tcaccctgcg gaaccgcaag ggctttgtga aactggccct gcgtcatgga gctgacctgg ttcccatcta ctcctttgga gagaatgaag tgtacaagca ggtgatcttc gaggagggct cctggggccg atgggtccag aagaagttcc agaaatacat tggtttcgcc ccatgcatct tccatggtcg aggcctcttc tcctccgaca cctgggggct ggtgccctac tccaagccca tcaccactgt tgtgggagag cccatcacca tccccaagct ggagcaccca acccagcaag acatcgacct gtaccacacc atgtacatgg aggccctggt gaagctcttc gacaagcaca agaccaagtt cggcctcccg gagactgagg tcctggaggt Protein function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT). Also able to use 1- monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). [The UniProt Consortium]