Tenoxicam

Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID) and COX-1 inhibitor (IC50 = 20 nM). It is selective for COX-1 over COX-2 (IC50 = 322 nM). Tenoxicam inhibits platelet aggregation induced by arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in washed isolated human platelets (IC50 = 0.16 µM). Topical application of a nanogel formulated with tenoxicam-containing solid lipid nanoparticles (SLNs) reduces paw thickness in a rat model of carrageenan-induced paw edema. Formulations containing tenoxicam have been used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.Formal Name: 4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide. CAS Number: 59804-37-4. Synonyms: Ro 12-0068. Molecular Formula: C13H11N3O4S2. Formula Weight: 337.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 20 mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL. lambdamax: 222, 270, 355 nm. SMILES: O=C(C(N1C)=C(O)C2=C(C=CS2)S1(=O)=O)NC3=CC=CC=N3. InChi Code: InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18). InChi Key: LZNWYQJJBLGYLT-UHFFFAOYSA-N.