Olsalazine-13C6

Olsalazine-13C6 is intended for use as an internal standard for the quantification of olsalazine (Cay-23661) by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (5-ASA, Cay-70265) that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA. In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of 5 mM. Olsalazine (150 mg/kg for 8 days) improves stool consistency and decreases occult and gross bleeding as well as myeloperoxidase (MPO) activity and leukotriene B4 (LTB4, Cay-20110) levels in colon tissue in a mouse model of acute colitis induced by dextran sulfate (Cay-23250). Olsalazine also inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L) and lowers serum uric acid levels in a mouse model of hyperuricemia induced by oxonic acid (Cay-22586) when administered at a dose of 20 mg/kg. Formulations containing olsalazine have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.Formal Name: (E)-5-((3-carboxy-4-hydroxyphenyl)diazenyl)-2-hydroxybenzoic-1,2,3,4,5,6-13C6 acid. Molecular Formula: C8[13C]6H10N2O6. Formula Weight: 308.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: OC(C1=C(O)C=CC(/N=N/[13C]2=[13CH][13C](C(O)=O)=[13C](O)[13CH]=[13CH]2)=C1)=O. InChi Code: InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+/i1+1,3+1,5+1,7+1,9+1,11+1. InChi Key: QQBDLJCYGRGAKP-FCGFREEASA-N.