NB-598

NB-598 is an inhibitor of squalene epoxidase (IC50s = 2 and 0.75 nM for dog liver and human microsomal enzymes, respectively). It selectively inhibits cholesterol synthesis over free fatty acid, triglyceride, and phospholipid synthesis in HepG2 cells at 1 µM. NB-598 (10 mg/kg per day) reduces serum cholesterol levels in dogs.Formal Name: 3-([3,3'-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl-benzenemethanamine. CAS Number: 131060-14-5. Molecular Formula: C27H31NOS2. Formula Weight: 449.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble (heated), Ethanol: Soluble (heated). lambdamax: 219 nm. SMILES: CCN(C/C=C/C#CC(C)(C)C)CC1=CC(OCC2=CC(C3=CSC=C3)=CS2)=CC=C1. InChi Code: InChI=1S/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+. InChi Key: KIRGLCXNEVICOG-SOFGYWHQSA-N.