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Liranaftate
Artikelnummer: Cay44439-10
Liranaftate is a thiocarbamate antifungal agent. It is active against T. rubrum (MIC = 0. g/ml). Liranaftate inhibits lung epithelial cell ferroptosis and malondialdehyde (MDA) production and reduces lung IL-6, IL-1beta, and TNF-alpha levels in a mouse model of acute lung injury induced by paraquat (Cay-38521)....
| Schlagworte: | M-732, Piritetrate, N-(6-methoxy-2-pyridinyl)-N-methyl-carbamothioic acid, O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester |
| Anwendung: | Thiocarbamate antifungal agent |
| CAS | 88678-31-3 |
| MW: | 328.43 D |
ab 48,00 €
Terbinafine (hydrochloride)
Artikelnummer: Cay10011619-100
Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. metagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 µg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 µM,...
| Schlagworte: | N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine, monohydrochloride |
| Anwendung: | Antifungal compound, ergosterol biosynthesis inhibitor |
| CAS | 78628-80-5 |
| MW: | 327.9 D |
ab 110,00 €
Naftifine (hydrochloride)
Artikelnummer: Cay19234-50
Naftifine is an allylamine compound that blocks ergosterol biosynthesis in fungi by inhibiting squalene epoxidase (Ki = 1.1 µM for C. albicans epoxidase).Formal Name: N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine, monohydrochloride. CAS Number: 65473-14-5. Synonyms: AW 105-843. Molecular Formula:...
| Schlagworte: | AW 105-843, N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-1-naphthalenemethanamine, monohydrochloride |
| Anwendung: | Squalene epoxidase inhibitor |
| CAS | 65473-14-5 |
| MW: | 323.9 D |
ab 57,00 €
Amorolfine (hydrochloride)
Artikelnummer: Cay26077-100
Amorolfine is an antifungal. It is active against isolates of T. rubrum, T. mentagrophytes, and C. albicans (MIC90s = 4-15, 4-60, and =30-500 ng/ml, respectively). It inhibits the growth of T. mentagrophytes and T. rubrum by 33.7 and 38.5%, respectively, in an in vitro bovine hoof model of onychomycosis. Amorolfine...
| Schlagworte: | Ro 14-4767/002, (2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, monohydrochloride |
| Anwendung: | Antifungal, ergosterol biosynthesis inhibitor |
| CAS | 78613-38-4 |
| MW: | 354 D |
ab 93,00 €
Tolnaftate
Artikelnummer: Cay21446-1
Tolnaftate is a thiocarbamate antifungal agent. It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8...
| Schlagworte: | NSC 233648, SCH 10144, N-methyl-N-(3-methylphenyl)-carbamothioic acid, O-2-naphthalenyl ester |
| Anwendung: | Antifungal, ergosterol biosynthesis inhibitor |
| CAS | 2398-96-1 |
| MW: | 307.4 D |
ab 57,00 €
Anti-SQLE / Squalene Epoxidase
Artikelnummer: ARG57421.100
Protein function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. [The UniProt Consortium]
| Schlagworte: | Anti-SE, Anti-ERG1, Anti-SQLE, EC=1.14.14.17, Anti-Squalene epoxidase, Anti-Squalene monooxygenase |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €
(±)-Alliin
Artikelnummer: Cay14001-10
Alliin is a cysteine sulfoxide constituent of garlic that is converted by alliinase to allicin, which imparts its pungent aroma and flavor. Alliin exhibits anti-cancer, anti-microbial, anti-hypertensive, cardioprotective, and anti-oxidant activities. It has been shown to inhibit squalene monooxygenase, a...
| Schlagworte: | (±)-Allyl-L-cysteine sulfoxide, S-2-propen-1-yl-S-oxide-L-cysteine |
| Anwendung: | Metabolic studies |
| CAS | 17795-26-5 |
| MW: | 177.2 D |
ab 127,00 €
Corilagin
Artikelnummer: Cay11832-1
Corilagin is a polyphenol and hydrolyzable tannin that can be isolated from a variety of plants. It inhibits squalene epoxidase (IC50 = 4.0 µM), a key enzyme in cholesterol synthesis. Corilagin also has various anti-inflammatory and anti-cancer effects.Formal Name: cyclic...
| Schlagworte: | cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate]... |
| Anwendung: | Squalene epoxidase inhibitor |
| CAS | 23094-69-1 |
| MW: | 634.5 D |
ab 49,00 €
Butenafine (hydrochloride)
Artikelnummer: Cay23797-1
Butenafine is a benzylamine antifungal agent that has broad-spectrum activity against 87 strains of dermatophytes (MICs = 0.0015-0.05 µg/ml), 15 strains of Aspergillus (MICs = 0.025-0.78 µg/ml), 4 strains of Cryptococcus (MICs = 0.78-1.56 µg/ml), and 67 strains of Candida (MICs = 3.13 to >100 µg/ml). It acts by...
| Schlagworte: | N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine, monohydrochloride |
| Anwendung: | Antifungal, ergosterol biosynthesis inhibitor, squalene epoxidase inhibitor |
| CAS | 101827-46-7 |
| MW: | 353.9 D |
ab 73,00 €
Terbinafine Hydrochloride
Artikelnummer: LKT-T1672.1
Allylamine, squalene oxidase and KSR1 inhibitor.
| Schlagworte: | Lamisil, N-[(2E)-6,6-Dimethyl-2-hepten-4-ynyl]-N-methyl-1- naphthalenemethanamine hydrochloride |
| Anwendung: | Anticancer agent, Squalene epoxidase inhibitor |
| CAS | 78628-80-5 |
| MW: | 327,9 D |
ab 100,00 €
Anti-SQLE
Artikelnummer: E-AB-63722.120
Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. Protein function: Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. [The UniProt...
| Schlagworte: | Anti-SE, Anti-SQLE, Anti-ERG1, EC=1.14.14.17, Anti-Squalene epoxidase, Anti-Squalene monooxygenase, SQLE Polyclonal Antibody |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 243,00 €
Terbinafine-d3 (hydrochloride)
Artikelnummer: Cay26392-1
Terbinafine-d3 is intended for use as an internal standard for the quantification of terbinafine (Cay-10011619) by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s =...
| Schlagworte: | N-[-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-(methyl-d3)-1-naphthalenemethanamine, monohydrochloride |
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, antifungal, ergosterol biosynthesis inhibitor |
| CAS | 1310012-15-7 |
| MW: | 330.9 D |
ab 130,00 €