H2L5186303

H2L5186303 is a selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 = 9 nM in a LPA-elicited calcium mobilization assay). It inhibits LPA1 and LPA3 at much higher concentrations (IC50s = 27,354 and 4,504 nM, respectively).Formal Name: (Z,Z)-4,4'-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid. CAS Number: 139262-76-3. Molecular Formula: C26H20N2O8. Formula Weight: 488.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.11 mg/ml, DMSO: 15 mg/ml. lambdamax: 298 nm. SMILES: O=C(/C=C\C(O)=O)NC(C=C1)=CC=C1OC2=CC(OC3=CC=C(NC(/C=C\C(O)=O)=O)C=C3)=CC=C2. InChi Code: InChI=1S/C26H20N2O8/c29-23(12-14-25(31)32)27-17-4-8-19(9-5-17)35-21-2-1-3-22(16-21)36-20-10-6-18(7-11-20)28-24(30)13-15-26(33)34/h1-16H,(H,27,29)(H,28,30)(H,31,32)(H,33,34)/b14-12-,15-13-. InChi Key: HZFPOTBCYPWQSH-DZDAAMPGSA-N.