Firocoxib

Firocoxib is a selective inhibitor of COX-2 (IC50s = 0.13 and 7.5 µM for COX-2 and COX-1, respectively, in isolated cat blood). It inhibits LPS-induced production of prostaglandin E2 (PGE2, Cay-14010) in isolated dog, horse, and cat whole blood ex vivo. Firocoxib decreases lameness, induces analgesia, and improves range of motion in dogs and horses with osteoarthritis when administered at doses of 5 and 0.1 mg/kg per day, respectively. Formulations containing firocoxib have been used in dogs and horses with osteoarthritis.Formal Name: 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone. CAS Number: 189954-96-9. Synonyms: ML-1785713. Molecular Formula: C17H20O5S. Formula Weight: 336.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 210, 220, 291 nm. SMILES: O=C1C(OCC2CC2)=C(C3=CC=C(S(C)(=O)=O)C=C3)C(C)(C)O1. InChi Code: InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3. InChi Key: FULAPETWGIGNMT-UHFFFAOYSA-N.