Desoximetasone

Desoximetasone is a glucocorticoid. In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.Formal Name: 9-fluoro-11beta,21-dihydroxy-16alpha-methyl-pregna-1,4-diene-3,20-dione. CAS Number: 382-67-2. Synonyms: A 41-304, 17-deoxy Dexamethasone, HOE 304. Molecular Formula: C22H29FO4. Formula Weight: 376.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 3 mg/ml. lambdamax: 237. SMILES: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@H]4C(CO)=O)=C1. InChi Code: InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1. InChi Key: VWVSBHGCDBMOOT-IIEHVVJPSA-N.