ZM 323881 (hydrochloride)

ZM 323881 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, IC50 = 50 = 8 nM) but not basal proliferation or that stimulated by EGF or bFGF (IC50s = >5,000, 1,900, and 1,600 nM, respectively).Formal Name: 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-phenol, monohydrochloride. CAS Number: 193000-39-4. Molecular Formula: C22H18FN3O2 . HCl. Formula Weight: 411.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. lambdamax: 250, 321 nm. SMILES: FC1=CC(C)=C(O)C=C1NC2=NC=NC3=CC(OCC4=CC=CC=C4)=CC=C32.Cl. InChi Code: InChI=1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15,/h2-11,13,27H,12H2,1H3,(H,24,25,26),1H. InChi Key: AVRHWGLIYGJSOD-UHFFFAOYSA-N.