YE 120

YE 120 is an agonist of G protein-coupled receptor 35 (GPR35) with an EC50 value of 32 nM in a dynamic mass redistribution (DMR) assay using HT-29 cells. It induces beta-arrestin translocation in Tango GPR35-bla U2OS cells (EC50 = 10.2 µM). YE 120 (10 µM) promotes wound closure in YAMC colonic epithelial and IEC-6 intestinal epithelial cell monolayers, an effect that can be blocked by the GPR35 antagonist CID-2745687 (Cay-12046).Formal Name: 2-[3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]-propanedinitrile. CAS Number: 383124-82-1. Molecular Formula: C16H9Cl2N3O. Formula Weight: 330.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: CC1=C(C#N)/C(OC1(C)C2=CC(Cl)=C(Cl)C=C2)=C(C#N)/C#N. InChi Code: InChI=1S/C16H9Cl2N3O/c1-9-12(8-21)15(10(6-19)7-20)22-16(9,2)11-3-4-13(17)14(18)5-11/h3-5H,1-2H3. InChi Key: RSWZFAPYKOARNG-UHFFFAOYSA-N.