WRN Inhibitor 8

WRN inhibitor 8 is an inhibitor of the DNA helicase Werner syndrome protein (WRN, IC50 = 48.3 nM). It inhibits the growth of HCT116 and SW480 colorectal cancer cells (GI50s = 0.01699 and 13.64 µM, respectively). SMILES FC(F)(C1CC1)C2=NC=C(C(OC3=CC=CC=C3)=N2)C(N[C@H](/C=C/S(=O)(C)=O)C4CC4)=O InChi Code InChI=1S/C22H23F2N3O4S/c1-32(29,30)12-11-18(14-7-8-14)26-19(28)17-13-25-21(22(23,24)15-9-10-15)27-20(17)31-16-5-3-2-4-6-16/h2-6,11-15,18H,7-10H2,1H3,(H,26,28)/b12-11+/t18-/m1/s1 InChi Key SGERSEZXZIVUEY-IENJSVCTSA-N