Zu "K10900" wurden 57 Artikel gefunden!
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WRN Inhibitor 8
Artikelnummer: Cay43724-1
WRN inhibitor 8 is an inhibitor of the DNA helicase Werner syndrome protein (WRN, IC50 = 48.3 nM). It inhibits the growth of HCT116 and SW480 colorectal cancer cells (GI50s = 0.01699 and 13.64 µM, respectively). SMILES FC(F)(C1CC1)C2=NC=C(C(OC3=CC=CC=C3)=N2)C(N[C@H](/C=C/S(=O)(C)=O)C4CC4)=O InChi Code...
| Schlagworte: | 2-(cyclopropyldifluoromethyl)-N-[(1S,2E)-1-cyclopropyl-3-(methylsulfonyl)-2-propen-1-yl]-4-phenoxy-5-pyrimidinecarboxamide |
| Anwendung: | WRN inhibitor |
| CAS | 3026502-95-1 |
| MW: | 463.5 D |
ab 216,00 €
Anti-WRN
Artikelnummer: A300-238A
The protein product of the Werners syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...
| Schlagworte: | Anti-Werner syndrome protein variant |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
Anti-WRN (IHC)
Artikelnummer: IHC-00407-T
The protein product of the Werners syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...
| Schlagworte: | Anti-Werner syndrome protein variant |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 165,00 €
NSC 617145
Artikelnummer: Cay21973-1
NSC 617145 is an inhibitor of WRN helicase (IC50 = 230 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only exhibiting 7% inhibition of RECQ1 at a concentration of 5 µM. NSC...
| Schlagworte: | 1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione |
| Anwendung: | WRN inhibitor |
| CAS | 203115-63-3 |
| MW: | 400 D |
ab 52,00 €
Anti-WRN
Artikelnummer: A300-239A
The protein product of the Werners syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...
| Schlagworte: | Anti-Werner syndrome protein variant |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
586,00 €
Anti-WRN
Artikelnummer: ARG59158.100
Protein function: Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates...
| Schlagworte: | Anti-WRN, Anti-RECQ3, Anti-RecQ3, EC=3.1.-.-, Anti-Exonuclease WRN, Anti-RecQ protein-like 2, Anti-DNA helicase, RecQ-like... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
707,00 €
Anti-WRN
Artikelnummer: E-AB-53558.120
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and...
| Schlagworte: | Anti-WRN, Anti-RECQ3, Anti-RecQ3, EC=3.1.-.-, Anti-Exonuclease WRN, Anti-RecQ protein-like 2, Anti-DNA helicase, RecQ-like... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 89,00 €
Anti-WRN
Artikelnummer: ATA-HPA028661.100
Protein function: Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates...
| Schlagworte: | Anti-WRN, Anti-RECQ3, Anti-RecQ3, EC=3.1.-.-, Anti-Exonuclease WRN, Anti-RecQ protein-like 2, Anti-DNA helicase, RecQ-like... |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
WRN, GST-Tag Recombinant
Artikelnummer: BPS-101264
Recombinant human WRN (Werner syndrome ATP-dependent helicase), encompassing amino acids 517-1093. This construct contains an N-terminal GST-tag followed by a Thrombin cleavage site. The recombinant protein was affinity purified.
| Schlagworte: | WRN, RECQ3, 3'-5' exonuclease, RecQ protein-like 2, ATP-dependent helicase, Werner syndrome protein, DNA helicase,... |
| Anwendung: | Immunotherapy studies |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 92 kD |
483,00 €
Anti-WRN
Artikelnummer: A300-239A-T
The protein product of the Werner's syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...
| Schlagworte: | Anti-WRN, Anti-RECQ3, Anti-RecQ3, EC=3.1.-.-, Anti-Exonuclease WRN, Anti-RecQ protein-like 2, Anti-DNA helicase, RecQ-like... |
| Anwendung: | WB, IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
165,00 €
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN...
Artikelnummer: CSB-EP614518HU1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 500-946aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: NLGLPTKEEE EDDENEANEG EEDDDKDFLW PAPNEEQVTC LKMYFGHSSF KPVQWKVIHS VLEERRDNVA VMATGYGKSL CFQYPPVYVG KIGLVISPLI SLMEDQVLQL...
| Schlagworte: | WRN, RECQ3, RecQ3, EC=3.1.-.-, Exonuclease WRN, RecQ protein-like 2, DNA helicase, RecQ-like type 3, Werner syndrome... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 58.3 kD |
ab 292,00 €
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN...
Artikelnummer: CSB-EP614518HU1a0.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 500-946aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: NLGLPTKEEE EDDENEANEG EEDDDKDFLW PAPNEEQVTC LKMYFGHSSF KPVQWKVIHS VLEERRDNVA VMATGYGKSL CFQYPPVYVG KIGLVISPLI SLMEDQVLQL KMSNIPACFL GSAQSENVLT DIKLGKYRIV...
| Schlagworte: | WRN, RECQ3, RecQ3, EC=3.1.-.-, Exonuclease WRN, RecQ protein-like 2, DNA helicase, RecQ-like type 3, Werner syndrome... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 56.8 kD |
ab 292,00 €