VUF 10166

VUF 10166 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3A (Ki = 0.04 nM). It is selective for 5-HT3A over 5-HT3AB receptors in radioligand binding assays (Ki = 2 nM), as well as alpha7 nicotinic acetylcholine receptors (nAChRs) at 100 µM. VUF 10166 also acts as a partial agonist at 5-HT3A receptors (EC50 = 5 µM in a patch-clamp assay using Xenopus oocytes expressing the human receptor).Formal Name: 2-chloro-3-(4-methyl-1-piperazinyl)-quinoxaline. CAS Number: 155584-74-0. Molecular Formula: C13H15ClN4. Formula Weight: 262.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 214, 259 nm. SMILES: ClC1=C(N2CCN(CC2)C)N=C3C=CC=CC3=N1. InChi Code: InChI=1S/C13H15ClN4/c1-17-6-8-18(9-7-17)13-12(14)15-10-4-2-3-5-11(10)16-13/h2-5H,6-9H2,1H3. InChi Key: FFXVTQDGTKEXHF-UHFFFAOYSA-N.