VU0119498

VU0119498 is a positive allosteric modulator (PAM) of M1, M3, and M5 muscarinic acetylcholine receptors (mAChRs, EC50s = 6.04, 6.38, and 4.08 µM, respectively, in calcium mobilization assays). It is selective for M1, M3, and M5 mAChRs over M2 and M4 mAChRs in CHO cells expressing the human receptors. VU0119498 (20 µM) enhances ACh-induced insulin secretion in MIN6-K8 pancreatic beta-cells. It decreases glucose tolerance and increases insulin secretion in mice fed normal chow, as well as in a mouse model of high-fat diet-induced obesity, when administered at a dose of 0.5 mg/kg.Formal Name: 1-[(4-bromophenyl)methyl]-1H-indole-2,3-dione. CAS Number: 79183-37-2. Molecular Formula: C15H10BrNO2. Formula Weight: 316.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 2 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. SMILES: O=C1C(N(CC2=CC=C(C=C2)Br)C3=C1C=CC=C3)=O. InChi Code: InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2. InChi Key: DELLOEULSHGYCG-UHFFFAOYSA-N.