Zu "K04131" wurden 94 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
CHO-K1/M3 Stable Cell Line
Artikelnummer: GSC-M00259
Recombinant CHO-K1 cells stably overexpress human cholinergic receptor muscarinic 3 (M3) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.
| Schlagworte: | CHRM3, Muscarinic acetylcholine receptor M3 |
11.424,00 €
Acetyl-beta-methylcholine (chloride)
Artikelnummer: Cay23092-5
Acetyl-beta-methylcholine is a muscarinic (M) receptor agonist. In wild-type mice, acetyl-beta-methylcholine decreases heart rate and blood pressure and increases the airway pressure time index, a measure of bronchoconstriction, in a dose-dependent manner. Cardiac and pulmonary responses are abolished in M2 and M3...
| Schlagworte: | Methacholine, 2-(acetyloxy)-N,N,N-trimethyl-1-propanaminium, monochloride |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 62-51-1 |
| MW: | 195.7 D |
ab 56,00 €
Darifenacin (hydrobromide)
Artikelnummer: Cay14424-10
Darifenacin is an antagonist of M3 muscarinic acetylcholine receptors (mAChRs, Ki = 0.76 nM). It is selective for M3 over M1, M2, M4, and M5 mAChRs (Kis = 7.08, 44.67, 45.71, and 9.33 nM, respectively). Darifenacin selectively inhibits contractions in isolated guinea pig ileum, bladder, and trachea (pA2s = 9.44,...
| Schlagworte: | UK 88525-04, 1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-alpha,alpha-diphenyl-3-pyrrolidineacetamide, monohydrobromide |
| Anwendung: | Muscarinic receptor antagonist |
| CAS | 133099-07-7 |
| MW: | 507.5 D |
ab 102,00 €
Tiotropium (bromide)
Artikelnummer: Cay15773-5
Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors). It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled...
| Schlagworte: | BA 679BR,... |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 136310-93-5 |
| MW: | 472.4 D |
ab 110,00 €
Tiotropium-d3 (bromide)
Artikelnummer: Cay25285-1
Tiotropium-d3 is intended for use as an internal standard for the quantification of tiotropium (Cay-15773) by GC- or LC-MS. Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors). It decreases...
| Schlagworte: | (1alpha,2beta,4beta,5alpha,7beta)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9-methyl-9-(methyl-d3)-3-oxa-9-azoniatricyclo[... |
| Anwendung: | GC-MS, LC-MS, internal standard |
| CAS | 1127226-56-5 |
| MW: | 475.4 D |
ab 228,00 €
Arecoline (hydrobromide)
Artikelnummer: Cay13662-500
Arecoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively. Generally, arecoline causes smooth muscle contraction. Arecoline and other muscarinic...
| Schlagworte: | 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, monohydrobromide |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 300-08-3 |
| MW: | 236.1 D |
ab 29,00 €
Solifenacin (succinate)
Artikelnummer: Cay17320-10
Solifenacin is a competitive antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (Kis = 25, 125, and 10 nM, respectively, for the human receptors). It inhibits calcium mobilization induced by carbachol (carbamoylcholine, Cay-14486) in isolated guinea pig detrusor muscle cells (Ki = 4 nM). Solifenacin...
| Schlagworte: | Isoprenalinoe sulfate, YM-67905, (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate,... |
| Anwendung: | Competitive muscarinic receptor antagonist |
| CAS | 242478-38-2 |
| MW: | 480.6 D |
ab 49,00 €
Scopolamine hydrobromide
Artikelnummer: LKT-S1059.5
An anticholinergic agent.
| Schlagworte: | Scopolamine hydrobromide trihydrate |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 114-49-8 |
| MW: | 438,32 D |
ab 114,00 €
Glycopyrrolate
Artikelnummer: Cay16498-25
Glycopyrrolate is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at concentrations of 0.01, 0.1, or 1 µM. Glycopyrrolate reduces post-prandial...
| Schlagworte: | AHR 504, NSC 250836, NSC 251251, NSC 251252, 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium,... |
| Anwendung: | Long-acting muscarinic receptor antagonist |
| CAS | 596-51-0 |
| MW: | 398.3 D |
ab 85,00 €
Darifenacin
Artikelnummer: LKT-D0169.10
| Anwendung: | Muscarinic acetylcholine receptor M3 antagonist |
| CAS | 133099-07-7 |
| MW: | 507,46 D |
ab 104,00 €
4-DAMP
Artikelnummer: Cay14574-50
4-DAMP is a potent antagonist of the muscarinic M3 receptor (pKi = 9.3). It is routinely used to study the regulation and functions of the M3 receptor. 4-DAMP also has a high affinity for the closely-related M5 receptor (pKi = 8.9).Formal Name: 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monoiodide. CAS...
| Schlagworte: | 4-Diphenylacetoxy-N-methyl-piperidine methiodide, 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monoiodide |
| Anwendung: | Muscarinic M3 receptor antagonist |
| CAS | 1952-15-4 |
| MW: | 451.3 D |
ab 62,00 €
Trospium (chloride)
Artikelnummer: Cay21279-500
Trospium is an antagonist of muscarinic (M) receptors (Kis = 0.50-2.3 nM for human M1-5 recombinant receptors, respectively). Formulations containing antimuscarinics, including trospium, are used to manage overactive bladder by relieving urgency, frequency, and incontinence.Formal Name:...
| Schlagworte: | Relaspium,... |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 10405-02-4 |
| MW: | 428 D |
ab 49,00 €